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<專題討論>2017/3/16(四)14:10綜合大樓2樓48218教室演講「Transport phenomena in the brain: from hydrocephalus to dementia」( 周鼎贏 博士 / Dept. of Engineering Science & Institute of Biomedical)

張貼者:2017年3月9日 下午10:28Dabby Lu

Cerebral tissue and related transport phenomena in the brain combine a number of characteristics that make their theoretical and computational representation and analysis particularly challenging: the brain has extreme metabolic and oxygenation needs but with minimal capacity to store glucose and oxygen, it is perfused by a markedly complex vascular system, it produces and floats in cerebrospinal fluid which is in continuous exchange with vascular plasma and – enclosed in the cranium – is probably the most inaccessible organ in the human body.

We propose a novel multiscale approach for addressing these modelling challenges that involve the representation of cerebral tissue as a porous elastic medium permeated by a multiplicity of passages – each with its own features (for instance, porosity and permeability) These networks have the potential to communicate with each other, according to predefined transport laws. We apply this new modelling framework to the case of Hydrocephalus – a disease that is equally important and paradoxical. Hydrocephalus can be succinctly described as the abnormal accumulation (imbalance between production and circulation) of cerebrospinal fluid within the brain. Using HCP as a test bed, one is able to account for the necessary mechanisms involved in the interaction between cerebral fluid production, transport and drainage. The model is discretised in a variety of formats, through the established finite difference method, finite difference – finite volume coupling and also the finite element method. Both chronic and acute hydrocephalus was investigated in a variety of settings, and accompanied by emerging surgical techniques where appropriate.

Dr Dean Chou was very recently awarded his D.Phil. degree from the University of Oxford (2011-2017). His research topic focuses on multi-scale cerebral mechanics. He received his first MSc. degree at the Department of Engineering Science and Ocean Engineering at the National Taiwan University (2002-2005). His second MSc. degree was awarded from the Department of Chemical and Material Engineering from the University of Alabama in Huntsville (2009-2010), where he received funding by CFD-ACE+ to aid the development of its macro-particle module. He is involved in the VPH-DARE@IT project since 2013.

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Dabby Lu,
2017年3月9日 下午10:28
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